Prognostic Value of the VHL, HIF-1α, and VEGF Signaling Pathway and Associated MAPK (ERK1/2 and ERK5) Pathways in Clear-Cell Renal Cell Carcinoma. A Long-Term Study.

doi:10.1016/j.clgc.2017.05.016

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Prognostic Value of the VHL, HIF-1α, and VEGF Signaling Pathway and Associated MAPK (ERK1/2 and ERK5) Pathways in Clear-Cell Renal Cell Carcinoma. A Long-Term Study.

Clinical genitourinary cancer - 1 Dec 2017

Salinas-Sánchez Antonio S, Serrano-Oviedo Leticia, Nam-Cha Syongh Y, Roche-Losada Olga, Sánchez-Prieto Ricardo, Giménez-Bachs José M

Abstract excerpt

BACKGROUND: The prognostic value of molecular markers in renal cell carcinoma has been investigated in several studies. Although their value is still not confirmed, various proteins are important. We describe the effect on long-term survival of the status of the von Hippel-Lindau (VHL) hypoxia-inducible factor 1-α (HIF1-α) signaling pathway as well as associated mitogen-activated protein kinase (extracellular...

Topics

Carcinoma, Renal Cell
Cell Line, Tumor
DNA Methylation
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

MAP Kinase Signaling System

Male

Mutation

Neoplasm Staging

Prognosis

Prospective Studies

Signal Transduction

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 28624320
DOI: 10.1016/j.clgc.2017.05.016

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