Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.

doi:10.1016/j.clgc.2018.01.013

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Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.

Clinical genitourinary cancer - 1 Aug 2018

Verbiest Annelies, Lambrechts Diether, Van Brussel Thomas, Couchy Gabrielle, Wozniak Agnieszka, Méjean Arnaud, Lerut Evelyne, Oudard Stéphane, Verkarre Virginie, Job Sylvie, de Reynies Aurélien, Machiels Jean-Pascal, Patard Jean-Jacques, Zucman-Rossi Jessica, Beuselinck Benoit

Abstract excerpt

BACKGROUND: Clear-cell renal-cell carcinoma (ccRCC) is characterized by loss of a functional Von Hippel-Lindau (VHL) protein. We investigated the potential of 3 single nucleotide polymorphisms (SNPs) in VHL as biomarkers in metastatic ccRCC (m-ccRCC) patients treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs). PATIENTS AND METHODS: We genotyped 3 VHL SNPs in 199...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Cell Dedifferentiation
DNA Methylation
Female
Humans
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Loss of Heterozygosity

Male

Middle Aged

Pharmacogenomic Variants

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Protein Kinase Inhibitors

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 29503246
DOI: 10.1016/j.clgc.2018.01.013

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