Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.

The Journal of biological chemistry - 30 Aug 2013

Lee Sei-Jung, No Yi Ran, Dang Duyen T, Dang Long H, Yang Vincent W, Shim Hyunsuk, Yun C Chris

Abstract excerpt

Hypoxia-inducible factor 1α (HIF-1α) and p53 are pivotal regulators of tumor growth. Lysophosphatidic acid (LPA) is a lipid mediator that functions as a mitogen by acting through LPA receptors. We have shown previously that LPA stimulates HIF-1α expression in colon cancer cells. To determine the mechanism of HIF-1α induction by LPA, we compared the effect of LPA on HIF-1α in several colon cancer cell lines. LPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kruppel-Like Transcription Factors

Share to Lysophospholipids

Share to Response Elements

Share to Trans-Activators

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 23880760
DOI: 10.1074/jbc.M113.489708
PMCID: PMC3757187

Genes

LPA
KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.PMID 23880760Read ↗

p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation.Semantic proximity Read ↗

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancerSemantic proximity Read ↗

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput ScreeningSemantic proximity Read ↗

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.Semantic proximity Read ↗

Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo.Semantic proximity Read ↗

Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.Semantic proximity Read ↗

Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer.Semantic proximity Read ↗

Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer.Semantic proximity Read ↗

The oxysterol receptors lxrα and lxrβ suppress proliferation in the colonSemantic proximity Read ↗

Role of human aquaporin 5 in colorectal carcinogenesis.Semantic proximity Read ↗

Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection.Semantic proximity Read ↗

Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.