Article
Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer.
Cancer research - 15 Oct 2011
Yang Yizeng, Nakagawa Hiroshi, Tetreault Marie-Pier, Billig Janelle, Victor Noel, Goyal Abha, Sepulveda Antonia R, Katz Jonathan P
Abstract excerpt
Squamous cell cancers account for more than half of all human cancers, and esophageal cancer is the sixth leading cause of cancer death worldwide. The majority of esophageal squamous cell carcinomas have identifiable p53 mutations, yet the same p53 mutations are found at comparable frequencies in precancerous dysplasia, indicating that transformation requires additional somatic changes yet to be defined. Here, we...
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