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The oxysterol receptors lxrα and lxrβ suppress proliferation in the colon

18 May 2012

Abstract excerpt

The oxysterol receptors LXRα and LXRβ are members of the nuclear receptor family and established transcriptional regulators of lipid metabolism with additional anti-inflammatory functions. Recent investigations have indicated an important role of LXRs in the control of proliferation. Here we further extend this knowledge to human colon cancer cells and proliferation in mouse colon. We show that activation of LXRs...

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PMID: 22610535
DOI: 10.1002/mc.21924

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