Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells.

The Journal of biological chemistry - 12 Oct 2012

Zhou Jundong, Zhang Shuyu, Xue Jing, Avery Jori, Wu Jinchang, Lind Stuart E, Ding Wei-Qun

Abstract excerpt

Activation of peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to inhibit tumor growth and angiogenesis, yet the mechanisms behind these actions remain to be characterized. In this study, we examined the effects of PPARα activation on the hypoxia-inducible factor-1α (HIF-1α) signaling pathway in human breast (MCF-7) and ovarian (A2780) cancer cells under hypoxia. Incubation of cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Cells
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PPAR alpha

Share to Proteasome Endopeptidase Complex

Share to Proteasome Inhibitors

Share to Proteolysis

Share to Vascular Endothelial Growth Factor A

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22932900
DOI: 10.1074/jbc.M112.367367
PMCID: PMC3471732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells.PMID 22932900Read ↗

Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα) regulates HIF2A transcription and correlates to poor outcomeSemantic proximity Read ↗

HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugsSemantic proximity Read ↗

Upregulation of CYP1B1 by hypoxia is mediated by ERα activation in breast cancer cellsSemantic proximity Read ↗

PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathwaySemantic proximity Read ↗

Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.Semantic proximity Read ↗

Hypoxic downregulation of cellular proliferation and loss of phenotype stability in human osteoblasts is mediated by HIF-1α.Semantic proximity Read ↗

Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysisSemantic proximity Read ↗

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T CellsSemantic proximity Read ↗

Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors.Semantic proximity Read ↗

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of CarcinogenesisSemantic proximity Read ↗

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.Semantic proximity Read ↗

Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of CarcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.