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Article

p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation.

Cell cycle (Georgetown, Tex.) - 1 Nov 2012

Yang Yizeng, Tarapore Rohinton S, Jarmel Melissa H, Tetreault Marie-Pier, Katz Jonathan P

Abstract excerpt

Krüppel-like factor 5 (KLF5) is a key transcriptional regulator that is typically pro-proliferative in non-transformed epithelial cells but inhibits proliferation in transformed epithelial cells. However, the underlying mechanisms for this context-dependent function are not known. KLF5 is epigenetically silenced and exhibits a tumor suppressive function in esophageal squamous cell cancer (ESCC). Since p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

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Source

Open in PubMed Open full text

Identifiers

PMID: 22990386
DOI: 10.4161/cc.22265
PMCID: PMC3507498

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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