Article
Linkage between increased nociception and olfaction via a SCN9A haplotype.
PloS one - 1 Jan 2013
Heimann Dirk, Lötsch Jörn, Hummel Thomas, Doehring Alexandra, Oertel Bruno G
Abstract excerpt
BACKGROUND AND AIMS: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level. We hypothesized that if such link exists, it should work in both directions and gain-of-function Nav1.7 mutations known to be associated with increased pain perception should also increase olfactory acuity....
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