Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels.

doi:10.1007/s00424-020-02419-9

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Article

Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels.

Pflugers Archiv : European journal of physiology - 1 Jul 2020

Baker Mark D, Nassar Mohammed A

Abstract excerpt

Chronic pain is a global problem affecting up to 20% of the world's population and has a significant economic, social and personal cost to society. Sensory neurons of the dorsal root ganglia (DRG) detect noxious stimuli and transmit this sensory information to regions of the central nervous system (CNS) where activity is perceived as pain. DRG neurons express multiple voltage-gated sodium channels that underlie...

Topics

Animals
Central Nervous System
Chronic Pain
Ganglia, Spinal
Humans
Mutation
NAV1.7 Voltage-Gated Sodium Channel
NAV1.9 Voltage-Gated Sodium Channel

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Identifiers

PMID: 32601768
DOI: 10.1007/s00424-020-02419-9
PMCID: PMC7351857

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