Article
Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli.
PloS one - 1 Jan 2014
Schütz Michael, Oertel Bruno G, Heimann Dirk, Doehring Alexandra, Walter Carmen, Dimova Violeta, Geisslinger Gerd, Lötsch Jörn
Abstract excerpt
BACKGROUND: TRPA1 ion channels are involved in nociception and are also excited by pungent odorous substances. Based on reported associations of TRPA1 genetics with increased sensitivity to thermal pain stimuli, we therefore hypothesized that this association also exists for increased olfactory sensitivity. METHODS: Olfactory function and nociception was compared between carriers (n = 38) and non-carriers...
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