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Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

10 Oct 2023

Abstract excerpt

The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37816865
DOI: 10.1038/s42003-023-05286-z

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