Article
Pain perception is altered by a nucleotide polymorphism in SCN9A.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Reimann Frank, Cox James J, Belfer Inna, Diatchenko Luda, Zaykin Dmitri V, McHale Duncan P, Drenth Joost P H, Dai Feng, Wheeler Jerry, Sanders Frances, Wood Linda, Wu Tian-Xia, Karppinen Jaro, Nikolajsen Lone, Männikkö Minna, Max Mitchell B, Kiselycznyk Carly, Poddar Minakshi, Te Morsche Rene H M, Smith Shad, Gibson Dustin, Kelempisioti Anthi, Maixner William, Gribble Fiona M, Woods C Geoffrey
Abstract excerpt
The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause a complete absence of pain, whereas activating mutations cause severe episodic pain in paroxysmal extreme pain disorder and primary erythermalgia. This led us to investigate whether single nucleotide polymorphisms (SNPs) in SCN9A were associated with differing pain perception in the general population. We first genotyped 27...
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