Article
Painful and painless channelopathies.
The Lancet. Neurology - 1 Jun 2014
Bennett David L H, Woods C Geoffrey
Abstract excerpt
The discovery of genetic variants that substantially alter an individual's perception of pain has led to a step-change in our understanding of molecular events underlying the detection and transmission of noxious stimuli by the peripheral nervous system. For example, the voltage-gated sodium ion channel Nav1.7 is expressed selectively in sensory and autonomic neurons; inactivating mutations in SCN9A, which...
Topics
- Calcium Channels
- Channelopathies
- Humans
- Mutation
- NAV1.7 Voltage-Gated Sodium Channel
- NAV1.8 Voltage-Gated Sodium Channel
- NAV1.9 Voltage-Gated Sodium Channel
- Nerve Tissue Proteins
- Pain
- TRPA1 Cation Channel
- Transient Receptor Potential Channels