Article
Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use.
The Lancet. Neurology - 1 Nov 2014
Waxman Stephen G, Merkies Ingemar S J, Gerrits Monique M, Dib-Hajj Sulayman D, Lauria Giuseppe, Cox James J, Wood John N, Woods C Geoffrey, Drenth Joost P H, Faber Catharina G
Abstract excerpt
Human studies have firmly implicated voltage-gated sodium channels in human pain disorders, and targeted and massively parallel genomic sequencing is beginning to be used in clinical practice to determine which sodium channel variants are involved. Missense substitutions of SCN9A, the gene encoding sodium channel NaV1.7, SCN10A, the gene encoding sodium channel NaV1.8, and SCN11A, the gene encoding sodium channel...
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