The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice

Abstract excerpt

The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these variants, their involvement in pain phenotype still needs to be experimentally elucidated. In order to delineate the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ion channel regulation and function
• Share to Neuroscience and Neuropharmacology Research
• Share to Pain Mechanisms and Treatments