Article
A SCN10A SNP biases human pain sensitivity.
Molecular pain - 1 Jan 2016
Duan Guangyou, Han Chongyang, Wang Qingli, Guo Shanna, Zhang Yuhao, Ying Ying, Huang Penghao, Zhang Li, Macala Lawrence, Shah Palak, Zhang Mi, Li Ningbo, Dib-Hajj Sulayman D, Waxman Stephen G, Zhang Xianwei
Abstract excerpt
BACKGROUND: Nav1.8 sodium channels, encoded by SCN10A, are preferentially expressed in nociceptive neurons and play an important role in human pain. Although rare gain-of-function variants in SCN10A have been identified in individuals with painful peripheral neuropathies, whether more common variants in SCN10A can have an effect at the channel level and at the dorsal root ganglion, neuronal level leading to a...
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