Article
Sodium channelopathies and pain.
Pflugers Archiv : European journal of physiology - 1 Jul 2010
Lampert Angelika, O'Reilly Andrias O, Reeh Peter, Leffler Andreas
Abstract excerpt
Chronic pain often represents a severe, debilitating condition. Up to 10% of the worldwide population are affected, and many patients are poorly responsive to current treatment strategies. Nociceptors detect noxious conditions to produce the sensation of pain, and this signal is conveyed to the CNS by means of action potentials. The fast upstroke of action potentials is mediated by voltage-gated sodium channels,...
Topics
- Animals
- Channelopathies
- Erythromelalgia
- Humans
- Migraine with Aura
- NAV1.1 Voltage-Gated Sodium Channel
- NAV1.7 Voltage-Gated Sodium Channel
- Nerve Tissue Proteins
- Nociceptors
- Pain
- Pain Insensitivity, Congenital