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A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin.

Pharmacogenetics and genomics - 1 Oct 2013

Christensen Mette M H, Pedersen Rasmus S, Stage Tore B, Brasch-Andersen Charlotte, Nielsen Flemming, Damkier Per, Beck-Nielsen Henning, Brøsen Kim

Abstract excerpt

OBJECTIVE: The aim of this study was to determine the association between the renal clearance (CL(renal)) of metformin in healthy Caucasian volunteers and the single-nucleotide polymorphism (SNP) c.808G>T (rs316019) in OCT2 as well as the relevance of the gene-gene interactions between this SNP and (a) the promoter SNP g.-66T>C (rs2252281) in MATE1 and (b) the OCT1 reduced-function diplotypes. METHODS: Fifty...

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PMID: 23873119
DOI: 10.1097/FPC.0b013e328364a57d

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