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Article

Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis.

Blood - 17 Oct 2013

Lechtenberg Bernhard C, Murray-Rust Thomas A, Johnson Daniel J D, Adams Ty E, Krishnaswamy Sriram, Camire Rodney M, Huntington James A

Abstract excerpt

The prothrombinase complex, composed of the protease factor (f)Xa and cofactor fVa, efficiently converts prothrombin to thrombin by specific sequential cleavage at 2 sites. How the complex assembles and its mechanism of prothrombin processing are of central importance to human health and disease, because insufficient thrombin generation is the root cause of hemophilia, and excessive thrombin production results in...

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Identifiers

PMID: 23869089
DOI: 10.1182/blood-2013-06-511733
PMCID: PMC3798993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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