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Article

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

Thrombosis and haemostasis - 1 Jan 2018

Ercig Bogac, Wichapong Kanin, Reutelingsperger Chris P M, Vanhoorelbeke Karen, Voorberg Jan, Nicolaes Gerry A F

Abstract excerpt

ADAMTS13 (A D: isintegrin A: nd M: etalloprotease with a T: hromboS: pondin type-1 motif, member 13: ) and von Willebrand factor (VWF) can be considered as scale weights which control platelet adhesion during primary haemostasis. In a very uncommon condition designated thrombotic thrombocytopenic purpura (TTP), functional absence of ADAMTS13 tips the balance toward VWF-mediated platelet adhesion in the...

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Source

Identifiers

PMID: 29304523
DOI: 10.1160/TH17-06-0404

Genes

ADAMTS13
VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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