Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa.

doi:10.1016/j.jtha.2025.10.015

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Article

Engineering a membrane-independent human prothrombinase through parsimonious mutation of factor Xa.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2026

Üstok Fatma Işık, Huntington James A

Abstract excerpt

BACKGROUND: Thrombin is generated from its precursor prothrombin by sequential cleavage at Arg320 and Arg271 by the prothrombinase complex, composed of factor (F)Xa and FVa on phospholipid (PL) surfaces. The affinity of human FXa for FVa is low in the absence of PL. However, FXa orthologs from the venom of group D snakes bind to FVa with high affinity, forming an active complex without PL. We previously...

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PMID: 41197805
DOI: 10.1016/j.jtha.2025.10.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.