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Article

Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity.

Blood - 30 Aug 2012

Gilbert Gary E, Novakovic Valerie A, Kaufman Randal J, Miao Hongzhi, Pipe Steven W

Abstract excerpt

Factor VIII and factor V share structural homology and bind to phospholipid membranes via tandem, lectin-like C domains. Their respective C2 domains bind via 2 pairs of hydrophobic amino acids and an amphipathic cluster. In contrast, the factor V-like, homologous subunit (Pt-FV) of a prothrombin activator from Pseudonaja textilis venom is reported to function without membrane binding. We hypothesized that the...

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Identifiers

PMID: 22613792
DOI: 10.1182/blood-2012-01-408245
PMCID: PMC3433094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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