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Article

Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases.

Journal of biochemistry - 1 Oct 2013

Moritani Mariko, Ishimi Yukio

Abstract excerpt

Cyclin-dependent kinase (CDK) that plays a central role in preventing re-replication of DNA phosphorylates several replication proteins to inactivate them. MCM4 in MCM2-7 and RPA2 in RPA are phosphorylated with CDK in vivo. There are inversed correlations between the phosphorylation of these proteins and their chromatin binding. Here, we examined in vitro phosphorylation of human replication proteins of MCM2-7,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23864661
DOI: 10.1093/jb/mvt062

Genes

MCM2
MCM4
CDK2
RECQL4
RPA2
CDC45
CDC7
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases.PMID 23864661Read ↗

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