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Article

Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.

The Journal of biological chemistry - 26 May 2000

Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M

Abstract excerpt

A strong body of evidence indicates that cyclin-dependent protein kinases are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. Mcm proteins are one of the components of the replication licensing system that permits only a single round of DNA replication per cell cycle. It has been reported that Mcm proteins are phosphorylated by the...

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Identifiers

PMID: 10748114
DOI: 10.1074/jbc.M909040199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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