Article
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation.
Medical mycology - 1 Nov 2013
Grube Matthias, Loeffler Juergen, Mezger Markus, Krüger Bernd, Echtenacher Bernd, Hoffmann Petra, Edinger Matthias, Einsele Hermann, Andreesen Reinhard, Holler Ernst
Abstract excerpt
Single nucleotide polymorphisms (SNPs) have been associated with an increased incidence of invasive aspergillosis (IA) after allogeneic stem cell transplantation (allo-SCT). We analyzed 41 patients with proven/probable IA after allo-SCT for an association of SNPs, within the TLR2, TLR4, TLR5, TLR9, and NOD2/CARD15 genes, with susceptibility to IA. The control group consisted of 130 patients who had allo-SCT but...
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