Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.

doi:10.1182/blood-2005-09-3741

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.

Blood - 15 May 2006

Holler Ernst, Rogler Gerhard, Brenmoehl Julia, Hahn Joachim, Herfarth Hans, Greinix Hildegard, Dickinson Anne M, Socié Gerard, Wolff Daniel, Fischer Gottfried, Jackson Graham, Rocha Vanderson, Steiner Beate, Eissner Guenther, Marienhagen Jeorg, Schoelmerich Juergen, Andreesen Reinhard

Abstract excerpt

To assess the role of NOD2/CARD15 variants on the long-term outcome of allogeneic stem cell transplantation in a genetically homogeneous group, we extended our previous study (cohort I, n = 78) and typed DNA for NOD2/CARD15 single nucleotide polymorphisms (SNPs) from an additional 225 recipients and their HLA-identical sibling donors (cohort II) treated at four other European centers. Results of genotyping were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hematologic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA Antigens

Share to Intracellular Signaling Peptides and Proteins

Share to Leukemia

Share to Nod2 Signaling Adaptor Protein

Share to Siblings

Share to Stem Cell Transplantation

Share to Transplantation, Homologous

Source

Open in PubMed

Identifiers

PMID: 16424393
DOI: 10.1182/blood-2005-09-3741

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination.PMID 16424393Read ↗

The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation.Semantic proximity Read ↗

Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.Semantic proximity Read ↗

Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation.Semantic proximity Read ↗

Polymorphisms within epithelial receptors: NOD2/CARD15.Semantic proximity Read ↗

Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Semantic proximity Read ↗

Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.Semantic proximity Read ↗

Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.Semantic proximity Read ↗

NOD2/CARD15 variants are not a risk factor for clinical outcome after nonmyeloablative allogeneic stem cell transplantation.Semantic proximity Read ↗

Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.Semantic proximity Read ↗

NOD2 polymorphisms predict severe acute graft-versus-host and treatment-related mortality in T-cell-depleted haematopoietic stem cell transplantation.Semantic proximity Read ↗

Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.Semantic proximity Read ↗

NOD2/CARD15 mutations and the risk of reoperation in patients with Crohns disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.