Article
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation.
The New England journal of medicine - 23 Oct 2008
Bochud Pierre-Yves, Chien Jason W, Marr Kieren A, Leisenring Wendy M, Upton Arlo, Janer Marta, Rodrigues Stephanie D, Li Sarah, Hansen John A, Zhao Lue Ping, Aderem Alan, Boeckh Michael
Abstract excerpt
BACKGROUND: Toll-like receptors (TLRs) are essential components of the immune response to fungal pathogens. We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants. METHODS: We analyzed 20 single-nucleotide polymorphisms (SNPs) in the toll-like receptor 2 gene (TLR2), the toll-like receptor 3 gene (TLR3), the toll-like...
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