Article
Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.
Transplantation - 27 Jan 2006
Elmaagacli Ahmet H, Koldehoff Michael, Hindahl Heidrun, Steckel Nina K, Trenschel Rudolf, Peceny Rudolf, Ottinger Hellmut, Rath Peter-Michael, Ross Rudolf Stefan, Roggendorf Michael, Grosse-Wilde Hans, Beelen Dietrich W
Abstract excerpt
BACKGROUND: NOD2 and TLR-4 genes belong to the innate immune system that detects invading pathogens through several pattern-recognition receptors. Here we analyzed 403 patients for NOD2 gene mutations and 307 patients for TLR-4 gene mutations (Thr399Ile) with their respective donors and correlated the results with the incidence of acute graft-versus-host disease (aGVHD), severe acute GVHD (saGVHD), the risk for...
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