Article
TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.
Annals of the New York Academy of Sciences - 1 Dec 2005
Kesh Sandra, Mensah Nana Yaa, Peterlongo Paolo, Jaffe Dana, Hsu Katharine, VAN DEN Brink Marcel, O'reilly Richard, Pamer Eric, Satagopan Jaya, Papanicolaou G A
Abstract excerpt
Toll-like receptors (TLRs) transmit signals in response to Aspergillus fumigatus conidia and hyphae. In this preliminary study, we examined the association between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell transplant recipients consisting of 22 patients with IA and 105 unaffected control subjects....
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