Article
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.
Nature communications - 6 Jul 2018
Gresnigt Mark S, Cunha Cristina, Jaeger Martin, Gonçalves Samuel M, Malireddi R K Subbarao, Ammerdorffer Anne, Lubbers Rosalie, Oosting Marije, Rasid Orhan, Jouvion Grégory, Fitting Catherine, Jong Dirk J de, Lacerda João F, Campos António, Melchers Willem J G, Lagrou Katrien, Maertens Johan, Kanneganti Thirumala-Devi, Carvalho Agostinho, Ibrahim-Granet Oumaima, van de Veerdonk Frank L
Abstract excerpt
Invasive aspergillosis (IA) is a severe infection that can occur in severely immunocompromised patients. Efficient immune recognition of Aspergillus is crucial to protect against infection, and previous studies suggested a role for NOD2 in this process. However, thorough investigation of the impact of NOD2 on susceptibility to aspergillosis is lacking. Common genetic variations in NOD2 has been associated with...
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