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Article

Influence of polymorphisms in innate immunity genes on susceptibility to invasive aspergillosis after stem cell transplantation.

PloS one - 4 Apr 2011

de Boer Mark G J, Jolink Hetty, Halkes Constantijn J M, van der Heiden Pim L J, Kremer Dennis, Falkenburg J H Frederik, van de Vosse Esther, van Dissel Jaap T

Abstract excerpt

The innate immune system plays a pivotal role in the primary defence against invasive fungal infection. Genetic variation in genes that regulate this response, initiated by pulmonary macrophages, may influence susceptibility to invasive aspergillosis in patients at risk. We investigated in a clinical setting whether common polymorphisms in Toll-like receptor (TLR) and cytokine genes involved in macrophage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21483748
DOI: 10.1371/journal.pone.0018403
PMCID: PMC3070725

Genes

TLR4
IFNG

Provenance

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