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Article

The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis.

The Journal of infectious diseases - 1 Mar 2011

Chai Louis Y A, de Boer Mark G J, van der Velden Walter J F M, Plantinga Theo S, van Spriel Annemiek B, Jacobs Cor, Halkes Constantijn J M, Vonk Alieke G, Blijlevens Nicole M, van Dissel Jaap T, Donnelly Peter J, Kullberg Bart-Jan, Maertens Johan, Netea Mihai G

Abstract excerpt

BACKGROUND: Dectin-1 is the major receptor for fungal β-glucans on myeloid cells. We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients. METHODS: Association of Dectin-1 Y238X polymorphism with occurrence and clinical course of IA was evaluated in 71 patients who developed IA post...

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Identifiers

PMID: 21242599
DOI: 10.1093/infdis/jiq102
PMCID: PMC3072717

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