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Article

NRAS and BRAF mutations in melanoma-associated nevi and uninvolved nevi.

PloS one - 1 Jan 2013

Tschandl Philipp, Berghoff Anna Sophie, Preusser Matthias, Burgstaller-Muehlbacher Sebastian, Pehamberger Hubert, Okamoto Ichiro, Kittler Harald

Abstract excerpt

According to the prevailing multistep model of melanoma development, oncogenic BRAF or NRAS mutations are crucial initial events in melanoma development. It is not known whether melanocytic nevi that are found in association with a melanoma are more likely to carry BRAF or NRAS mutations than uninvolved nevi. By laser microdissection we were able to selectively dissect and genotype cells either from the nevus or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23861977
DOI: 10.1371/journal.pone.0069639
PMCID: PMC3704624

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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