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Article

BRAF somatic mutations in malignant melanoma and melanocytic naevi.

Melanoma research - 1 Apr 2006

Thomas Nancy E

Abstract excerpt

BRAF somatic mutations are frequently found in primary and metastatic melanomas and melanocytic naevi. Commonly found BRAF mutants stimulate constitutive RAF/MEK (mitogen-activated ERK-activating kinase)/ERK (extracellular signal-regulated kinase) pathway activation and act as transforming oncogenes in NIH-3T3 cells and immortalized murine melanocytes. The most common BRAF mutation is the V600E alteration, but...

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Identifiers

PMID: 16567964
DOI: 10.1097/01.cmr.0000215035.38436.87

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BRAF
NRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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