Article
High frequency of BRAF mutations in nevi.
Nature genetics - 1 Jan 2003
Pollock Pamela M, Harper Ursula L, Hansen Katherine S, Yudt Laura M, Stark Mitchell, Robbins Christiane M, Moses Tracy Y, Hostetter Galen, Wagner Urs, Kakareka John, Salem Ghadi, Pohida Tom, Heenan Peter, Duray Paul, Kallioniemi Olli, Hayward Nicholas K, Trent Jeffrey M, Meltzer Paul S
Abstract excerpt
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma...
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