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Article

Concordant BRAFV600E mutation status in primary melanomas and associated naevi: implications for mutation testing of primary melanomas.

Pathology - 1 Apr 2014

Kakavand Hojabr, Crainic Oana, Lum Trina, O'Toole Sandra A, Kefford Richard F, Thompson John F, Wilmott James S, Long Georgina V, Scolyer Richard A

Abstract excerpt

There is concern that BRAF mutant naevus cells admixed with melanoma cells could cause false positive mutation tests in BRAF wild-type melanomas. We sought to assess the frequency of BRAF(V600E) mutations in primary melanomas arising with/without associated naevi and determine BRAF(V600E) concordance between melanomas and associated naevi. Formalin fixed, paraffin embedded (FFPE) tissue from 57 patients with...

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PMID: 24614711
DOI: 10.1097/PAT.0000000000000077

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BRAF

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