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Article

Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia.

Journal of the National Cancer Institute - 19 Jun 2013

Yeh Iwei, von Deimling Andreas, Bastian Boris C

Abstract excerpt

BRAF(V600E) mutations are frequent in melanomas originating from intermittently sun-exposed skin and also in common acquired melanocytic nevi, suggesting that BRAF mutation is an early event in melanocytic neoplasia. All neoplastic melanocytes within such a nevus would be expected to carry the BRAF mutation, and thus we evaluated the frequency of cells with BRAF(V600E) mutations within acquired nevi by droplet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 23690527
DOI: 10.1093/jnci/djt119
PMCID: PMC3687371

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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