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Article

In melanocytic lesions the fraction of BRAF V600E alleles is associated with sun exposure but unrelated to ERK phosphorylation.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 2008

Venesio Tiziana, Chiorino Giovanna, Balsamo Antonella, Zaccagna Alessandro, Petti Consalvo, Scatolini Maria, Pisacane Alberto, Sarotto Ivana, Picciotto Franco, Risio Mauro

Abstract excerpt

BRAF(V600E) mutation has been frequently reported in different types of melanocytic lesions, but its role in melanomagenesis is poorly understood, having been associated with either the proliferative-induced MAPK pathway activation or the acquisition of oncogene-driven senescence. The presence of BRAF alterations has been related to sun exposure, although the molecular mechanisms underlying this event are only...

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Source

Identifiers

PMID: 18408659
DOI: 10.1038/modpathol.2008.41

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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