NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.

doi:10.1097/01.cmr.0000232300.22032.86

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Article

NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing.

Melanoma research - 1 Dec 2006

Edlundh-Rose Esther, Egyházi Suzanne, Omholt Katarina, Månsson-Brahme Eva, Platz Anton, Hansson Johan, Lundeberg Joakim

Abstract excerpt

We have previously demonstrated the use of pyrosequencing to investigate NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog] mutations in melanoma biopsies. Here, we expanded the analysis to include BRAF (V-raf murine sarcoma viral oncogene homolog B1), another member of the Ras-Raf-mitogen-activated protein kinase (MAPK) signalling pathway, and analysed a total of 294 melanoma tumours from 219 patients....

Topics

Adult
Aged
Aged, 80 and over
DNA Mutational Analysis
DNA, Neoplasm
Female
Genes, ras
Genotype
Humans
Male
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Nevus, Pigmented

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Proto-Oncogene Mas

Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 17119447
DOI: 10.1097/01.cmr.0000232300.22032.86

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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