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Article

Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 May 2010

Picton Anabela C P, Paximadis Maria, Tiemessen Caroline T

Abstract excerpt

Polymorphisms within the open reading frame as well as the promoter and regulatory regions can influence the amount of CCR5 expressed on the cell surface and hence an individual's susceptibility to HIV-1. In this study we characterize CCR5 genes within the South African African (SAA) and Caucasian (SAC) populations by sequencing a 9.2kb continuous region encompassing the CCR5 open reading frame (ORF), its two...

Topics

Black People
Chromosome Mapping
Genetic Predisposition to Disease
HIV Infections
HIV-1
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Receptors, CCR5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

South Africa

White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20206716
DOI: 10.1016/j.meegid.2010.02.012
PMCID: PMC2877777

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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