Article
HLA-E coding and 3' untranslated region variability determined by next-generation sequencing in two West-African population samples.
Human immunology - 1 Dec 2015
Castelli Erick C, Mendes-Junior Celso T, Sabbagh Audrey, Porto Iane O P, Garcia André, Ramalho Jaqueline, Lima Thálitta H A, Massaro Juliana D, Dias Fabrício C, Collares Cristhianna V A, Jamonneau Vincent, Bucheton Bruno, Camara Mamadou, Donadi Eduardo A
Abstract excerpt
HLA-E is a non-classical Human Leucocyte Antigen class I gene with immunomodulatory properties. Whereas HLA-E expression usually occurs at low levels, it is widely distributed amongst human tissues, has the ability to bind self and non-self antigens and to interact with NK cells and T lymphocytes, being important for immunosurveillance and also for fighting against infections. HLA-E is usually the most conserved...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.