Article
Olanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system.
Psychoneuroendocrinology - 1 Nov 2013
Girault Elodie M, Toonen Pim W, Eggels Leslie, Foppen Ewout, Ackermans Mariëtte T, la Fleur Susanne E, Fliers Eric, Kalsbeek Andries
Abstract excerpt
Atypical antipsychotic drugs such as Olanzapine (Ola) induce weight gain and metabolic changes associated with the development of type 2 diabetes. The mechanisms underlying these undesired side-effects are currently unknown. Chagnon et al. showed that the common allele rs7973796 of the prepro-melanin-concentrating hormone (PMCH) gene is associated with a greater body mass index in Ola-treated schizophrenic...
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