Chemogenetic inhibition of the lateral hypothalamus in rats: A simple but robust tool with high translational relevance to facilitate the development of central nervous system-targeted gene therapies

Abstract excerpt

<title>Abstract</title> <p>Aims Despite the therapeutic potential of chemogenetics, the method lacks comprehensive preclinical validation, hindering its progression to human clinical trials. We aimed to validate a robust but simple in vivo assay in rats, which could support chemogenetic drug discovery. We also aimed to establish the proof-of-concept for the chemogenetic approach in obesity indication. Methods K...

Topics

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• Drug Design
• Gene Expression Regulation
• Ligands
• Molecular Targeted Therapy
• Protein Engineering
• Receptors, G-Protein-Coupled
• Signal Transduction
• Translational Research, Biomedical

Identifiers and source

Literature Corpus work

e1f604b8-4fa8-5bb4-a4ba-93768f8df5d7

DOI

10.21203/rs.3.rs-3620463/v1