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Article

Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients.

Journal of clinical psychopharmacology - 1 Feb 2013

Tiwari Arun K, Brandl Eva J, Weber Caroline, Likhodi Olga, Zai Clement C, Hahn Margaret K, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Müller Daniel J

Abstract excerpt

Significant body weight gain (BWG) is a serious adverse effect of a number of antipsychotic drugs. Previous studies have demonstrated an influence of clozapine, but not haloperidol, on neuropeptide Y (NPY) expression in the hypothalamus. Because NPY is a potent orexigenic peptide stimulating food intake, and genetic variation of the gene has been shown to influence development of obesity, we investigated the...

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Source

Identifiers

PMID: 23277265
DOI: 10.1097/JCP.0b013e31827d145a

Genes

NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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