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Article

Regulation of melanocortin-4-receptor (MC4R) expression by SNP rs17066842 is dependent on glucose concentration.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Aug 2020

Qin Li, Tiwari Arun K, Zai Clement C, Freeman Natalie, Zhai Dongxu, Liu Fang, Stachelscheid Harald, Mergenthaler Philipp, Kennedy James L, Müller Daniel J

Abstract excerpt

Melanocortin-4-receptor (MC4R) gene codes for a G-protein-coupled receptor that is highly expressed in the hypothalamus and involved in the regulation of appetite. Single-nucleotide polymorphisms (SNPs) in the MC4R gene region have been associated with obesity, type 2-diabetes (T2D) and with antipsychotic-induced weight gain. Of these, rs17066842 (G>A) in the MC4R promoter region is the top variant associated...

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PMID: 32684494
DOI: 10.1016/j.euroneuro.2020.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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