Article
Investigation of melanocortin system gene variants in antipsychotic-induced weight gain.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2014
Chowdhury Nabilah I, Souza Renan P, Tiwari Arun K, Brandl Eva J, Sicard Michelle, Meltzer Herbert Y, Lieberman Jeffrey A, Kennedy James L, Müller Daniel J
Abstract excerpt
OBJECTIVES: The use of second-generation antipsychotic medications may result in substantial weight gain in a subset of schizophrenia patients. Distinct populations of neurons expressed in the hypothalamus, including the cocaine- and amphetamine-regulated transcript (CART), the polypeptide pro-opiomelanocortin (POMC) and the agouti-related protein (AGRP), have regulatory roles in weight control and energy...
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