Article
Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.
Scientific reports - 1 Jan 2011
Furukawa Toru, Kuboki Yuko, Tanji Etsuko, Yoshida Shoko, Hatori Takashi, Yamamoto Masakazu, Shibata Noriyuki, Shimizu Kyoko, Kamatani Naoyuki, Shiratori Keiko
Abstract excerpt
Intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic cystic neoplasm that is often invasive and metastatic, resulting in a poor prognosis. Few molecular alterations unique to IPMN are known. We performed whole-exome sequencing for a primary IPMN tissue, which uncovered somatic mutations in KCNF1, DYNC1H1, PGCP, STAB1, PTPRM, PRPF8, RNASE3, SPHKAP, MLXIPL, VPS13C, PRCC, GNAS, KRAS, RBM10, RNF43,...
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