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Article

Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013

Huang Li-Hao, Gui Jingang, Artinger Erika, Craig Ruth, Berwin Brent L, Ernst Patricia A, Chang Catherine C Y, Chang Ta-Yuan

Abstract excerpt

OBJECTIVE: To investigate the role of acyl-CoA:cholesterol acyltransferase 1 (ACAT1) in hematopoiesis. APPROACH AND RESULTS: ACAT1 converts cellular cholesterol to cholesteryl esters for storage in multiple cell types and is a potential drug target for human diseases. In mouse models for atherosclerosis, global Acat1 knockout causes increased lesion size; bone marrow transplantation experiments suggest that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23846496
DOI: 10.1161/ATVBAHA.112.301080
PMCID: PMC3882116

Genes

ACAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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