Article
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Willner Emily L, Tow Bryan, Buhman Kimberly K, Wilson Martha, Sanan David A, Rudel Lawrence L, Farese Robert V
Abstract excerpt
Deficiency of acyl CoA:cholesterol acyltransferase 2 (ACAT2) in mice results in a reduction in cholesterol ester synthesis in the small intestine and liver, which in turn limits intestinal cholesterol absorption, hepatic cholesterol gallstone formation, and the accumulation of cholesterol esters in the plasma lipoproteins. Here we examined the contribution of ACAT2-derived cholesterol esters to atherosclerosis by...
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