Article
Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.
American journal of medical genetics. Part A - 1 Aug 2013
Billingsley Cherie N, Allen Jared R, Baumann Douglas D, Deitz Samantha L, Blazek Joshua D, Newbauer Abby, Darrah Andrew, Long Brad C, Young Brandon, Clement Mark, Doerge R W, Roper Randall J
Abstract excerpt
Trisomy 21 in humans causes cognitive impairment, craniofacial dysmorphology, and heart defects collectively referred to as Down syndrome. Yet, the pathophysiology of these phenotypes is not well understood. Craniofacial alterations may lead to complications in breathing, eating, and communication. Ts65Dn mice exhibit craniofacial alterations that model Down syndrome including a small mandible. We show that...
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